The House of Lusignan is a royal house of French origin, which at various times ruled several principalities in Europe and the Levant, including the kingdoms of Jerusalem, Cyprus, and Armenia, from the 12th through the 15th centuries during the Middle Ages. It also had great influence in England and France.

The family originated in Lusignan, in Poitou, western France, in the early 10th century.

By the end of the 11th century, the family had risen to become the most prominent petty lords in the region from their castle at Lusignan.

In the late 12th century, through marriages and inheritance, a cadet branch of the family came to control the kingdoms of Jerusalem and Cyprus.

In the early 13th century, the main branch succeeded to the Counties of La Marche and Angoulême.

As Crusader kings in the Latin East, they soon had connections with the Hethumid rulers of the Kingdom of Cilicia, which they inherited through marriage in the mid-14th century.

The Armenian branch fled to France, and eventually Russia, after the Mamluk conquest of their kingdom.

The claim was taken by the Cypriot branch, until their line failed. This kingdom was annexed by the Republic of Venice in the late 15th century.

The Château de Lusignan, near Poitiers, was the principal seat of the Lusignans. It is shown at its height in the March illumination in the Trés Riches Heures of the Duc de Berry (circa 1412).

Louis XIV fortified it and it was used as a prison, a school—and a handy quarry for building materials.

It was leveled to the ground in the 18th century in order to create a park for local residents.

Only its foundations remain today. According to folklore, the earliest castle was built by Melusine, a water-spirit.

The lords of the castle at Lusignan became counts of La Marche in the 12th century.

They added the county of Angoulême to their holdings in 1220, when Hugh X of Lusignan married Isabella of Angoulême, daughter of Count Aymer of Angoulême and widow of John, King of England.

These acquisitions produced complicated titles. For example, Hugh XI of Lusignan was Hugh VI of La Marche and Hugh II of Angoulême.

Hugh XIII died in 1303. His sisters, Jeanne and Isabelle, sold the county of Angoulême to Philip IV of France.

Hugh was succeeded by his brother, Guy I, who died in 1308, making their sister Yolande Countess of La Marche. After Yolande's death, in 1314, King Philip annexed La Marche.